The eight-times world billiard champion cruised into the last eight with a 4-1 win over Scotland’s Graeme Dott and sealed the historic landmark in style with a break of 100.
Dott joins fellow former world champions Shaun Murphy and Peter Ebdon (qualifiying) to have been outdone by the rising star from Pune.
Advani will face an exciting quarter-final tie on Friday against Judd Trump who continued to show signs of returning to form in a 4-1 win over Andrew Higginson.
Ding Junhui made it a step closer to defending his Welsh Open title after a 4-2 win over Mark Allen .
Next up for the China star is Gloucestershire’s Robert Milkins who fought off last 16 first-timer Sam Baird by the same score to make the last eight stage.
Elsewhere, Alan McManus continued his fine run in Newport after pulling off the mother of all comebacks. Joe Perry, who yesterday stormed into the last 16 after whitewashing Mark Selby, enjoyed a 3-0 lead but McManus had other ideas winning the final four frames to make a rare quarter-final appearance.
Another Scot who enjoyed success on Day 4 was Stephen Maguire who ended the chances of a Welshman winning the tournament for the first time since 1999 after he beat Matthew Stevens.
This season’s Premier League champion Stuart Bingham increased his chances of winning his second world ranking title after beating Neil Robertson.
Robertson looked set to clinch when he was leading 64-9 in the final frame. But when the Australian missed a tough red it resulted in a stunning 56 clearance from Bingham to steal the match. After the game Bingham said it was one of the best clearances of his career.
Bingham will next face former world champion Ken Doherty who followed up his first round win against John Higgins by beating Tom Ford in another final frame decider.
Welsh Open 2013 – Quarter-Final Draw: (Matches first to 5 frames)
Ding JUNHUI vs Robert MILKINS
Stuart BINGHAM vs Ken DOHERTY
Judd TRUMP vs Pankaj ADVANI
Stephen MAGUIRE vs Alan McMANUS